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KMID : 0667720070440000451
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Report Natlonal Institute of Health
2007 Volume.44 No. 0 p.451 ~ p.454
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Associations of UCP2-UCP3 genetic variants with obesity in 7-year-old Korean children
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Kim In-Kyoung
Kang Jae-Heon
Shin Hyoung-Doo
Song Ji-Hyun
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Abstract
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Purpose : We investigated the associations of uncoupling protein (UCP)2 and UCP3 gene variants with obesity and related traits in Korean children and adults.
Methods : We genotyped UCP2-866G>A, UCP2 Ala55Val, UCP3-55C>T for 741 Korean children and 732 adults and collected data regarding anthropometric status and blood biochemistry. Information concerning the children’s lifestyles and dietary habits were collected. Logistic regression analysis was used to evaluate the association between obesity and UCP2-UCP3 genetic variants.
Results : The UCP2-866G>A and UCP3-55C>T gene variants showed significant associations with BMI level, waist circumference, and body weight in the children but not in the adults. Compared with -866GG carriers, the -866GA and AA carriers showed reduced risk for obesity (OR, 0.67; 95% CI, 0.45?1.01; P=0.05). In comparison with UCP3-55CC carriers, children carrying -55CT and TT showed reduced risk for obesity (OR, 0.67; 95% CI, 0.46?0.99; P=0.05). There was also evidence of interactions between the effects of the combined UCP2-UCP3 genotype and obesity-related metabolic traits (BMI, P=0.03; body weight, P=0.005; waist circumferences, P=0.002; serum total cholesterol, P=0.02). The greatest protective effect against obesity was seen in those with the combined genotype non-UCP2-866GG and non-UCP3-55CC, as compared with those carrying both UCP2?866GG and UCP3?55CC. In the subgroup with a low level of physical activity, UCP3?55CC carriers had higher BMI values than UCP3-55T carriers (16.6 ± 2.3 kg/m2 vs. 16.0 ± 1.7 kg/m2). Low physical activity may aggravate the susceptibility to obesity in UCP2-866GG and UCP3-55CC carriers.
Conclusions : UCP2 and UCP3 gene should still be considered as a candidate gene for children obesity since the UCP2-866A and UCP3-55T showed the protective effect against obesity. UCP3 -55T variant can have a protective role against fat accumulation, particularly in those individuals with a low level of physical activity.
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KEYWORD
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Korean children, UCP2, UCP3, polymorphism, obesity, BMI
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